Effects of geniposide on cerebral ischemia/reperfusion-induced neuron damage by inhibiting autophagy via cGAS-STING
GEN demonstrates potent neuroprotective effects against cerebral ischemia-reperfusion injury by mitigating neuronal apoptosis and improving neurological functions. These effects are attributed to their ability to modulate autophagy by inhibiting the cGAS-STING pathway. These findings highlight GEN as a promising therapeutic candidate for ischemic stroke treatment.
Authors
- Yuewang Yang (ORCID: https://orcid.org/0000-0003-2287-4289)
- Hu Xiamin
- Zhao Wei (ORCID: https://orcid.org/0000-0002-2400-3252)
- Yilin Wang (ORCID: https://orcid.org/0000-0001-5320-0274)
- Ma Fuyun
- Ye Yuhang
- Han Qiuqin
- Gao Ce
- Leng Xiaoru
- Yao Jiacheng
Institutions
- Shanghai University of Medicine and Health Sciences (CN)
- Wuhan University of Science and Technology (CN)
Publication Details
- Journal
- Neuropharmacology
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1016/j.neuropharm.2025.110677
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00