Pre-surgery gut microbial diversity and abundance are associated with post-surgery onset of cachexia in colorectal cancer patients: the ColoCare Study
Higher gut microbial alpha-diversity and lower relative abundances of the genera Porphyromonas and Actinomyces in pre-surgery stool samples were associated with onset of cachexia in CRC patients six months post-surgery. This is the first study to explore a link between the gut microbiome and cachexia in CRC patients, providing novel insights into the biology of cachexia and potential clinical interventions.
Authors
- Victoria Damerell
- Cornelia M. Ulrich (ORCID: https://orcid.org/0000-0001-7641-059X)
- Doratha A. Byrd (ORCID: https://orcid.org/0000-0003-4275-7901)
- David Shibata (ORCID: https://orcid.org/0000-0002-5670-423X)
- Jane C. Figueiredo (ORCID: https://orcid.org/0000-0002-2452-3194)
- Jolanta Jedrzkiewicz (ORCID: https://orcid.org/0000-0002-9408-3139)
- Sheetal Hardikar (ORCID: https://orcid.org/0000-0003-0292-6168)
- Christopher I. Li (ORCID: https://orcid.org/0000-0003-1543-0743)
- K. Nathan Sankar (ORCID: https://orcid.org/0000-0001-8636-8479)
- Caroline Himbert (ORCID: https://orcid.org/0000-0003-4084-8340)
- Biljana Gigic (ORCID: https://orcid.org/0000-0002-8085-2072)
- Maria F. Gomez (ORCID: https://orcid.org/0000-0001-6210-3142)
- Christoph Kahlert (ORCID: https://orcid.org/0000-0003-4124-7918)
- Mmadili N. Ilozumba (ORCID: https://orcid.org/0000-0002-9928-3711)
- June L. Round (ORCID: https://orcid.org/0000-0002-7158-9874)
- Erin M. Siegel (ORCID: https://orcid.org/0000-0003-1779-2510)
- Andreana N. Holowatyj (ORCID: https://orcid.org/0000-0001-8001-8793)
- Tengda Lin (ORCID: https://orcid.org/0000-0001-5147-8432)
- Christy A. Warby (ORCID: https://orcid.org/0000-0003-1772-8332)
- Bartley Pickron (ORCID: https://orcid.org/0000-0002-0880-1959)
- Jennifer Ose (ORCID: https://orcid.org/0000-0002-2030-9676)
- Gary Chris Fillmore
- W. Zac Stephens (ORCID: https://orcid.org/0000-0002-8072-9023)
- Adetunji T. Toriola (ORCID: https://orcid.org/0000-0003-1079-2606)
Institutions
- Cedars-Sinai Medical Center (US)
- Harvard University (US)
- University of Tennessee Health Science Center (US)
- Washington University in St. Louis (US)
- University of Utah (US)
- Heidelberg University (DE)
- Huntsman Cancer Institute (US)
- University Hospital Heidelberg (DE)
- Moffitt Cancer Center (US)
- Massachusetts General Hospital (US)
- Fred Hutch Cancer Center (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Cancer Causes & Control
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1007/s10552-025-02042-y
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Utah
- Deutsches Krebsforschungszentrum
- Huntsman Cancer Foundation
- Deutschen Konsortium für Translationale Krebsforschung
- National Institutes of Health
- National Cancer Institute