Electrochemotherapy of spinal metastasis using transpedicular approach: a preclinical safety animal study

Electrochemotherapy is a new treatment for vertebral metastases not accessible to radiotherapy, but it could result in spinal cord injury related to electrical trauma. In a swine model, the transpedicular approach has demonstrated no definitive sequelae at intraoperative neuromonitoring and during clinical follow-up. Electrochemotherapy should be performed using a transpedicular approach to avoid spinal cord damage.