Treatment-Related Changes in Cerebrospinal Fluid Markers of Oxidative Stress and Neurodegeneration during Therapy for Childhood Acute Lymphoblastic Leukemia
The clinical relevance of the putative biomarkers reported here will be validated by testing whether they are predictive of treatment-related cognitive decline. These biomarkers may then serve as surrogate markers for testing the efficacy of protective interventions designed to protect against treatment-induced neurotoxicity and cognitive decline.
Authors
- Alysta Paneque (ORCID: https://orcid.org/0009-0008-7650-5917)
- Jérèmy Willekens (ORCID: https://orcid.org/0000-0001-8960-3710)
- Bruno Michon (ORCID: https://orcid.org/0009-0007-1804-6487)
- Robert C. Daly (ORCID: https://orcid.org/0009-0000-6972-5518)
- Melissa Burns (ORCID: https://orcid.org/0000-0002-0953-766X)
- Chadni Patel (ORCID: https://orcid.org/0000-0003-2302-0453)
- Lewis B. Silverman (ORCID: https://orcid.org/0009-0007-7275-7650)
- Yongkyu Park (ORCID: https://orcid.org/0000-0001-6741-6447)
- Beth Savage (ORCID: https://orcid.org/0000-0001-6118-4120)
- Haiqun Lin (ORCID: https://orcid.org/0000-0002-3114-9671)
- Peter D. Cole (ORCID: https://orcid.org/0000-0002-3525-8015)
- Justine M. Kahn (ORCID: https://orcid.org/0000-0003-3330-6754)
- Thai Hoa Tran (ORCID: https://orcid.org/0000-0002-8712-6233)
- Jennifer Welch (ORCID: https://orcid.org/0000-0001-9117-4812)
- Stephen A. Sands (ORCID: https://orcid.org/0000-0003-4550-263X)
- Kara M. Kelly (ORCID: https://orcid.org/0000-0003-1473-3937)
- Lisa Gennarini (ORCID: https://orcid.org/0009-0009-3888-2997)
- Alexandra Thrope (ORCID: https://orcid.org/0009-0005-0228-2843)
- K C Nirajan
Institutions
- Rutgers, The State University of New Jersey (US)
- Roswell Park Comprehensive Cancer Center (US)
- Memorial Sloan Kettering Cancer Center (US)
- John Brown University (US)
- Brown University (US)
- Columbia University Irving Medical Center (US)
- Johnson University (US)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Centre hospitalier universitaire de Québec (CA)
- Children's Hospital at Montefiore (US)
- Montefiore Hospital (GB)
- Dana-Farber/Boston Children's Cancer and Blood Disorders Center (US)
- Rutgers Cancer Institute (US)
Publication Details
- Journal
- Cancer Epidemiology Biomarkers & Prevention
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1158/1055-9965.epi-25-1058
- Citations
- 1
- Primary Topic
- Cancer-related cognitive impairment studies
- Type
- article
- Field-Weighted Citation Impact
- 1.52