Advanced lung cancer inflammation index as a new predictor for colon cancer in elderly patients: an NHANES-based study
This study demonstrated that ALI, a nutritional-inflammation prognostic index, is significantly and inversely associated with the risk of colon cancer in older adults. Thus, ALI may serve as a promising, non-invasive biomarker for risk stratification, particularly among high-risk subgroups such as unmarried females, alcohol consumers, and those with lower BMI. Its strong predictive value, confirmed by machine learning, supports its potential role in personalized prevention. Further studies are required to explore underlying mechanisms, including dietary and microbial factors.
Authors
- Wenxuan Wu (ORCID: https://orcid.org/0009-0005-9627-4202)
- Jingyuan Wan (ORCID: https://orcid.org/0000-0002-1773-6474)
- Suhua Liu
- Haiqin Liu (ORCID: https://orcid.org/0000-0001-9028-3144)
- Yisheng Chen (ORCID: https://orcid.org/0000-0001-6498-7519)
- Hangyan Zhong
- Youlong Fan
- Meifang He
- Rongqi Lin (ORCID: https://orcid.org/0009-0006-1290-2054)
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
- Sun Yat-sen University (CN)
- Longyan University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Seventh People's Hospital of Shanghai (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-09-04
- DOI
- https://doi.org/10.3389/fnut.2025.1642913
- Citations
- 1
- Primary Topic
- Inflammatory Biomarkers in Disease Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Sanming Project of Medicine in Shenzhen
- Basic and Applied Basic Research Foundation of Guangdong Province