Acquired immunity mechanisms in sheep infected with Nematodirus oiratianus: key genes and host responses
Infection triggered early immune activation mediated by intestinal epithelial cells. Key differentially expressed genes included <i>CLDN18</i>, <i>CCL19</i>, <i>FGB</i>, and <i>Muc5ac</i>, potentially linking to parasite expulsion. Early-stage pathway enrichment in cancer, chemokine signaling, and phagosome function enhanced intestinal barrier integrity and immune cell recruitment. Late-stage upregulation of <i>CCL</i> chemokines directly impacted nematode survival. Intestinal villi shedding was also correlated with parasite clearance. These findings unravel potential mechanisms of acquired immunity against <i>Nematodirus oiratianus</i>, highlighting novel therapeutic targets (e.g., epithelial barrier regulators, chemokine networks) and vaccine candidates for nematode control in livestock.
Authors
- Ran Zhao (ORCID: https://orcid.org/0000-0001-7781-5820)
- Xuedong Ding (ORCID: https://orcid.org/0000-0002-1873-8711)
- Rongchun Han (ORCID: https://orcid.org/0000-0001-7520-9413)
- Xiaojia Mu
- Yilong Hao
- Li Xu
- Pingsheng Hao (ORCID: https://orcid.org/0000-0002-0376-6269)
- Surong Hasi (ORCID: https://orcid.org/0000-0002-7128-6849)
- Xiuli Peng (ORCID: https://orcid.org/0000-0001-5210-6999)
- Rina Su (ORCID: https://orcid.org/0009-0005-3239-1389)
- Yali Wang (ORCID: https://orcid.org/0000-0002-8414-5762)
- Bin Hou (ORCID: https://orcid.org/0000-0002-1858-2294)
- Fei Mao
- Risu Na (ORCID: https://orcid.org/0000-0002-6189-5640)
- Wu Bo
- Qimuge Bainuwen
- Dalai Suyala
Institutions
- Inner Mongolia Agricultural University (CN)
- Inner Mongolia Electric Power (China) (CN)
- Baotou Teachers College (CN)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2025-09-04
- DOI
- https://doi.org/10.3389/fvets.2025.1643786
- Primary Topic
- Helminth infection and control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Inner Mongolia