Anti-Bredt-Like Triterpenoids from Mycelial Cultures of the Edible Mushroom <i>Oudemansiella</i> cf. <i>canarii</i>
Sixteen undescribed triterpene glycosides, oudecanarins A-P (<b>1</b>-<b>16</b>), were isolated from cultures of basidiomycete <i>Oudemansiella</i> cf. <i>canarii</i> TBRC-BCC 85371. Oudecanarins A-G (<b>1</b>-<b>7</b>) contain a bicyclo[4.3.1]decene system bearing the bridgehead double bond as a DE ring of pentacyclic triterpene. The unique carbon skeleton was confirmed by the X-ray crystallographic analysis of oudecanarin B (<b>2</b>). The proposed plausible late-stage biosynthetic pathway for oudecanarin A (<b>1</b>) was supported by chemical conversion experiments.
Authors
- Panida Chinthanom
- Teera Chantarojsiri (ORCID: https://orcid.org/0000-0002-4951-9503)
- Vanicha Vichai (ORCID: https://orcid.org/0000-0002-3778-2080)
- Masahiko Isaka (ORCID: https://orcid.org/0000-0002-9229-3394)
- Malipan Sappan
- Thitiya Boonpratuang (ORCID: https://orcid.org/0000-0001-6942-2701)
Institutions
- National Science and Technology Development Agency (TH)
- Mahidol University (TH)
- Center for Innovation (US)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1021/acs.orglett.5c03296
- Citations
- 1
- Primary Topic
- Fungal Biology and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Mahidol University
- National Research Council of Thailand