Prognosis and Biological Characteristics of ER-Low Metastatic Breast Cancer: Results from a Multicenter Cohort and the TONIC Trial
We provided evidence of the prognostic role of ER-low expression and its dynamics in patients with HER2- metastatic breast cancer. We offered insights into sensitivity to anti-PD1 in metastatic breast cancer, showing that patients with ER-low breast cancer have comparable likelihood of responding to nivolumab as those with TNBC.
Authors
- Davide Massa (ORCID: https://orcid.org/0000-0002-1390-4055)
- Giuseppe Fotia (ORCID: https://orcid.org/0000-0002-2071-8971)
- Claudio Vernieri (ORCID: https://orcid.org/0000-0003-1577-8176)
- Federica Miglietta (ORCID: https://orcid.org/0000-0001-6203-874X)
- Angelo Paolo Dei Tos (ORCID: https://orcid.org/0000-0002-1228-8940)
- Valerio Pellegrini (ORCID: https://orcid.org/0000-0002-8438-8318)
- Andrea Vingiani (ORCID: https://orcid.org/0000-0002-9827-3976)
- Andrea Botticelli (ORCID: https://orcid.org/0000-0002-6425-9893)
- Valentina Guarneri (ORCID: https://orcid.org/0000-0002-2375-8397)
- Francesca Porra (ORCID: https://orcid.org/0009-0008-4560-6678)
- Matteo Fassan (ORCID: https://orcid.org/0000-0001-6515-5482)
- Francesca Schiavi (ORCID: https://orcid.org/0000-0001-8529-4455)
- Tommaso Giarratano (ORCID: https://orcid.org/0000-0002-6746-8877)
- Marleen Kok (ORCID: https://orcid.org/0000-0001-9043-9815)
- Giancarlo Pruneri (ORCID: https://orcid.org/0000-0002-7963-7172)
- Maria Vittoria Dieci (ORCID: https://orcid.org/0000-0002-3967-9861)
- Lorenzo Nicolè (ORCID: https://orcid.org/0000-0001-8126-9674)
- Gaia Griguolo (ORCID: https://orcid.org/0000-0002-8782-4509)
- Federico Piacentini (ORCID: https://orcid.org/0000-0001-8969-638X)
- Matilde Cacciatore (ORCID: https://orcid.org/0009-0002-3631-053X)
- Manon De Graaf (ORCID: https://orcid.org/0009-0008-3598-3293)
Institutions
- University of Modena and Reggio Emilia (IT)
- University of Padua (IT)
- University of Milan (IT)
- Dutch Cancer Society (NL)
- Policlinico Umberto I (IT)
- The Netherlands Cancer Institute (NL)
- AULSS 2 Marca Trevigiana (IT)
- Istituto Oncologico Veneto (IT)
- Oncode Institute (NL)
- Ospedale dell' Angelo (IT)
- Ca' Foncello Hospital (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-1796
- Primary Topic
- Advanced Breast Cancer Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00