Regioselective Pd-Catalyzed Hydroalkynylation of Allenyl-Containing α-Amino Acid Derivatives with Terminal Alkynes
An efficient access to the novel representatives of α,α-disubstituted α-amino acids with 1,3-enyne unit located at their side chain has been elaborated. The method is based on Pd(II)-catalyzed hydroalkynylation of α-allenyl-α-dimethylamino esters with terminal acetylenes. The developed strategy is the first example of the metal-catalyzed allene-alkyne coupling to provide a convenient route to new unsaturated α-amino acid derivatives in good yields and high selectivity.
Authors
- Anna N. Philippova (ORCID: https://orcid.org/0000-0002-6108-5103)
- Ivan A. Godovikov (ORCID: https://orcid.org/0000-0001-5822-323X)
- Sergey N. Osipov (ORCID: https://orcid.org/0000-0001-5625-776X)
- Daria V. Vorobyeva (ORCID: https://orcid.org/0000-0002-7325-6504)
- Pavel S. Gribanov (ORCID: https://orcid.org/0000-0003-3820-5442)
- Alexandra S. Bubnova
- Evgenia P. Antoshkina
Institutions
- A. N. Nesmeyanov Institute of Organoelement Compounds (RU)
Publication Details
- Journal
- Molecules
- Published
- 2025-09-04
- DOI
- https://doi.org/10.3390/molecules30173623
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Russian Science Foundation
- Ministry of Science and Higher Education of the Russian Federation