From protocol to practice: long-Term outcomes of single-Fraction stereotactic body radiotherapy for primary non-Small cell lung cancer
High-dose (≥ 30 Gy) single-fraction SBRT provides excellent long-term tumor control with minimal toxicity with NSCLC. Advanced motion management techniques were associated with reduced pulmonary toxicity. A ≥ 30 Gy dose significantly improved LC, PFS, and OS. Higher Charlson Comorbidity Index (CCI) was associated with worse OS. These findings support the use of high-dose SF-SBRT in selected patients and highlight the need for individualized treatment planning. Prospective validation is warranted.
Authors
- Angélique Holland
- Klemens Zink (ORCID: https://orcid.org/0000-0001-5785-4101)
- Hilke Vorwerk (ORCID: https://orcid.org/0000-0001-7542-683X)
- Ahmed Gawish (ORCID: https://orcid.org/0000-0001-5557-7438)
- Khaled Elsayad (ORCID: https://orcid.org/0000-0001-9303-7336)
- Niklas Recknagel
- Sebastian Adeberg (ORCID: https://orcid.org/0000-0001-8463-514X)
- Andreas Kirschbaum (ORCID: https://orcid.org/0000-0003-4987-8036)
- Thomas Wündisch
- Rita Engenhart‐Cabillic (ORCID: https://orcid.org/0000-0002-7444-9033)
- Kerem Tuna Tas
- Edgar Smalec
- Phillip Lishewski
- Fatima Frosan Sheikhzadeh
Institutions
- Goethe University Frankfurt (DE)
- Philipps University of Marburg (DE)
- Universitätsklinikum Gießen und Marburg (DE)
- University Hospital Frankfurt (DE)
- Technische Hochschule Mittelhessen (DE)
Publication Details
- Journal
- Strahlentherapie und Onkologie
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1007/s00066-025-02462-4
- Primary Topic
- Lung Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Philipps-Universität Marburg