The Relationship Between Blood Lipidomics and Cardiotoxic Injury Following Acute Exposure to Anthracycline Chemotherapy in Women With Breast Cancer: A Feasibility Study
OA<sub>4</sub>CL and OA in RBCs appear to be related to subclinical markers of cardiotoxicity in women with breast cancer undergoing AC. Larger studies are needed to investigate potential cardioprotective effects of dietary linoleic acid and LA<sub>4</sub>CL against AC.This trial was registered at clinicaltrials.gov as NCT03961685.
Authors
- Rachel M. Cole
- Martha A. Belury (ORCID: https://orcid.org/0000-0002-6480-4281)
- Patrick Ruz
- Genevieve C. Sparagna (ORCID: https://orcid.org/0000-0001-9543-4626)
- Ai Ni (ORCID: https://orcid.org/0000-0003-3002-3556)
- Daniel Addison (ORCID: https://orcid.org/0000-0002-9113-8333)
- Kate Marris
Institutions
- The Ohio State University Wexner Medical Center (US)
- University of Colorado Anschutz Medical Campus (US)
- The Ohio State University (US)
Publication Details
- Journal
- Current Developments in Nutrition
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1016/j.cdnut.2025.107552
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Cancer Institute
- National Center for Advancing Translational Sciences