Microbiota-Dependent Fiber Responses: A Proof-of-Concept Study on Short-Chain Fatty Acid Production in Prevotella- and Bacteroides-Dominated Healthy Individuals
B-types exhibited fiber-specific shifts in SCFA and BCFA metabolism and breath hydrogen, whereas P-types displayed a more limited overall response, with fewer metabolic and microbial parameters affected. These findings highlight the complexity of diet-microbiota interactions and support the potential relevance for microbiota-based nutrition strategies. This trial (PERIFIB) was registered at the German Clinical Trials register (DRKS) as DRKS00028898.
Authors
- Andreas Hahn (ORCID: https://orcid.org/0000-0001-8459-6582)
- Marius Vital
- Freek G. Bouwman (ORCID: https://orcid.org/0000-0002-5582-1370)
- Shoma Berkemeyer (ORCID: https://orcid.org/0000-0002-2125-7468)
- Sabrina Woltemate (ORCID: https://orcid.org/0009-0000-9495-470X)
- Mattea Müller (ORCID: https://orcid.org/0000-0002-3340-5122)
- Madeline Bartsch (ORCID: https://orcid.org/0009-0002-7505-9763)
Institutions
- Leibniz University Hannover (DE)
- Osnabrück University (DE)
- Maastricht University (NL)
- Medizinische Hochschule Hannover (DE)
- Hochschule Osnabrück (DE)
Publication Details
- Journal
- Journal of Nutrition
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1016/j.tjnut.2025.08.034
- Citations
- 7
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 5.64