A Synthetic Sponge System Against miRNAs of the miR-17/92 Cluster Targets Transcriptional MYC Dosage Compensation in Aneuploid Cancer
Our findings demonstrate that miRNA sponges targeting the miR-17/92 cluster can effectively disrupt MYC dosage compensation, leading to selective cytotoxicity in MYC-amplified cancer cells.
Authors
- Carsten Geiß (ORCID: https://orcid.org/0000-0001-9572-2476)
- Rodrígo Mora (ORCID: https://orcid.org/0000-0001-7964-3575)
- Steve Quirós (ORCID: https://orcid.org/0000-0002-9377-0199)
- Diana M. Bravo‐Estupiñan (ORCID: https://orcid.org/0009-0000-0416-9290)
- Mariela Montaño-Samaniego (ORCID: https://orcid.org/0000-0003-3516-0736)
- Christian Marín‐Müller
- Ricardo Chinchilla (ORCID: https://orcid.org/0000-0002-7839-5677)
- Jean-Claude Régnier (ORCID: https://orcid.org/0000-0001-6992-9027)
- Miguel Ángel Ibáñez-Hernández (ORCID: https://orcid.org/0000-0003-4013-6888)
- Jorge L. Arias-Arias (ORCID: https://orcid.org/0000-0001-7872-1068)
Institutions
- Johannes Gutenberg University Mainz (DE)
- Universidad de Costa Rica (CR)
- Hospital Nacional de Niños (CR)
- National Academy of Sciences (CR)
- Instituto Politécnico Nacional (MX)
Publication Details
- Journal
- Cells
- Published
- 2025-09-04
- DOI
- https://doi.org/10.3390/cells14171384
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Instituto Politécnico Nacional
- Universidad de Costa Rica