Clinical and pathophysiological roles of lower lobe–dominant mucus plugs on computed tomography in patients with asthma with and without bronchiectasis
Lower lobe-dominant mucus plugs were associated with lower lung function and exacerbations in patients with asthma, irrespective of comorbid bronchiectasis. The spatial distribution of mucus plugs additionally to whole-lung mucus plug score may help to understand clinical roles of mucus plugging in asthma.
Authors
- Yusuke Hayashi (ORCID: https://orcid.org/0000-0001-5672-1497)
- Susumu Satô (ORCID: https://orcid.org/0000-0002-9626-1090)
- Sumito Inoue
- Mikio Toyoshima (ORCID: https://orcid.org/0000-0002-8349-0142)
- Noboru Hattori (ORCID: https://orcid.org/0000-0002-8234-942X)
- Hisako Matsumoto (ORCID: https://orcid.org/0000-0002-8754-6318)
- Osamu Matsuno (ORCID: https://orcid.org/0000-0003-0926-9674)
- Mari Miki (ORCID: https://orcid.org/0000-0002-6642-4987)
- Takahiro Tsuburai (ORCID: https://orcid.org/0000-0003-1968-1806)
- Naoya Tanabe (ORCID: https://orcid.org/0000-0002-7481-0212)
- Natsuko Nomura
- Hironobu Sunadome (ORCID: https://orcid.org/0000-0002-4617-2348)
- Naozumi Hashimoto (ORCID: https://orcid.org/0000-0003-2337-629X)
- Morio Nakamura (ORCID: https://orcid.org/0000-0002-0140-6155)
- Kazuto Matsunaga (ORCID: https://orcid.org/0000-0002-0514-3241)
- Takuro Sakagami (ORCID: https://orcid.org/0000-0002-9057-1127)
- Takashi Kijima
- Hiroyuki Nagase (ORCID: https://orcid.org/0000-0002-0296-5901)
- Hiroaki Iijima (ORCID: https://orcid.org/0000-0003-4621-2394)
- Ryo Sakamoto (ORCID: https://orcid.org/0000-0003-1382-8803)
- Atsuyasu Sato (ORCID: https://orcid.org/0000-0001-8068-9984)
- Tetsuji Kawamura
- Toyohiro Hirai
- Toshiyuki Kita
- Nobuyuki Hizawa
- Taisuke Tsuji
- Koichi Fukunaga
- Kojiro Otsuka
Institutions
- Yamagata University (JP)
- Hiroshima University (JP)
- Fujita Health University (JP)
- University of Tsukuba (JP)
- St. Marianna University School of Medicine (JP)
- Yamaguchi University (JP)
- Keio University (JP)
- Kyoto University (JP)
- Osaka Prefectural Medical Center (JP)
- Kanazawa Medical Center (JP)
- Yokohama City Seibu Hospital (JP)
- Toneyama National Hospital (JP)
- Naruto, Tokushima Prefecture hospital (JP)
- Hamamatsu Rosai Hospital (JP)
- Himeji Medical Center (JP)
- Takatsuki Red Cross Hospital (JP)
- Kyoto first Red Cross hospital (JP)
- Saiseikai Central Hospital (JP)
- Shinko Hospital (JP)
- Tsukuba Medical Center Hospital (JP)
- Nagoya University (JP)
- Hyogo University (JP)
- Teikyo University (JP)
- Kindai University (JP)
- Kumamoto University (JP)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology Global
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1016/j.jacig.2025.100566
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japanese Respiratory Society
- Japan Society for the Promotion of Science