Hepatotoxicity induced by polylactic acid microplastics: The mediating role of gut microbiota and uric acid metabolism
Our findings demonstrate that PLA MP-induced liver damage is mediated by gut microbiota-driven elevation of uric acid. This highlights the critical role of systemic factors, particularly gut microbiota, in assessing the hepatotoxicity of PLA MPs.
Authors
- Yujie Feng (ORCID: https://orcid.org/0000-0002-0686-3937)
- Ruobing Bai (ORCID: https://orcid.org/0000-0002-5847-0502)
- Yanhong Deng (ORCID: https://orcid.org/0000-0001-6873-8026)
- Xiyun Huang
- Alex Qiu (ORCID: https://orcid.org/0000-0003-4243-1856)
- Yuji Huang
- Zhenlie Huang (ORCID: https://orcid.org/0000-0001-9818-8192)
- Hongyi Xian
- Yizhou Zhong
- Hao Li (ORCID: https://orcid.org/0000-0002-5607-9438)
- Xiaohong Chen (ORCID: https://orcid.org/0000-0002-9797-8384)
- Da Chen (ORCID: https://orcid.org/0000-0001-5563-0091)
- Zhiming Li (ORCID: https://orcid.org/0009-0000-7497-3559)
- Bingchi Fan
- Boxuan Liang
- Xiaohong Yang
Institutions
- Jinan University (CN)
- National Medical Products Administration (CN)
- Zhujiang Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.jare.2025.08.055
- Citations
- 8
- Primary Topic
- Microplastics and Plastic Pollution
- Type
- article
- Field-Weighted Citation Impact
- 4.03