[18F]FDG-PET provides insights into the liver-brain axis and confirms SUV as a surrogate for MR in a mouse model of liver fibrosis
[<sup>18</sup>F]FDG PET imaging revealed that liver fibrosis alters glucose metabolism in both liver and brain, emphasizing the potential of molecular imaging for future assessment of metabolic interaction between liver and brain. [<sup>18</sup>F]FDG uptake in terms of SUV<sub>gluc</sub> strongly correlated with MR<sub>Glu</sub> from kinetic modeling, supporting its utility as a valid surrogate parameter to quantify cerebral glucose metabolism in mice.
Authors
- Thomas Wanek (ORCID: https://orcid.org/0000-0002-0404-4452)
- Mari Teuter
- Tobias L. Roß (ORCID: https://orcid.org/0000-0002-0101-2463)
- Frank M. Bengel (ORCID: https://orcid.org/0000-0003-4529-7963)
- Marion Bankstahl (ORCID: https://orcid.org/0000-0002-5775-188X)
- Michael Ott
- Asha Balakrishnan (ORCID: https://orcid.org/0000-0002-1366-3386)
- Jens P. Bankstahl (ORCID: https://orcid.org/0000-0003-4735-4490)
Institutions
- University of Veterinary Medicine Vienna (AT)
- University of Veterinary Medicine Hannover, Foundation (DE)
- Medizinische Hochschule Hannover (DE)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Nuclear Medicine and Biology
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1016/j.nucmedbio.2025.109095
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00