Low synaptic and neurosecretory proteins in cerebrospinal fluid in early parkinsonian disease
Low CSF levels of biomarkers associated with synaptic and neurosecretory function (e.g., NPTX1) implicate age-independent synaptic dysfunction as a shared, early feature in the pathogenesis of PD, MSA, and PSP. Such biomarkers may be particularly sensitive correlates of early non-motor dysfunction. Early axonal dysfunction is more pronounced in PSP and MSA than in PD.
Authors
- Radu Constantinescu (ORCID: https://orcid.org/0000-0001-5408-5167)
- Julius Constantinescu (ORCID: https://orcid.org/0009-0008-5132-268X)
- Ann Brinkmalm (ORCID: https://orcid.org/0000-0002-7396-3233)
- David Bäckström (ORCID: https://orcid.org/0000-0002-4417-2475)
- Kaj Blennow (ORCID: https://orcid.org/0000-0002-1890-4193)
- Protik Jakobsson (ORCID: https://orcid.org/0000-0002-9033-3559)
- Johanna Nilsson (ORCID: https://orcid.org/0000-0002-2856-6060)
- Henrik Zetterberg
- Maria Nygren
Institutions
- University of Gothenburg (SE)
- Umeå University (SE)
Publication Details
- Journal
- Journal of the Neurological Sciences
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1016/j.jns.2025.123683
- Citations
- 2
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.78