Development of a biorelevant dissolution method for inhalation products: Proof of concept using drugs with diverse solubilities
The obtained results indicated that the investigated products would not be considered bioequivalent based on the aerodynamic particle size distribution. It was demonstrated that a discriminative dissolution method can be developed through a well-established paradigm of dissolution testing, while taking into account the specificities of the inhalation route of administration.
Authors
- Jelena Parojčić (ORCID: https://orcid.org/0000-0001-8074-6221)
- Alisa Elezović (ORCID: https://orcid.org/0000-0003-0559-1463)
- Saša Pilipović (ORCID: https://orcid.org/0000-0001-7574-5881)
- Sandra Cvijić (ORCID: https://orcid.org/0000-0001-8291-791X)
- Amar Elezović (ORCID: https://orcid.org/0000-0001-9832-9135)
Institutions
- University of Sarajevo (BA)
- University of Belgrade (RS)
- Academy of Medical Sciences of Bosnia and Herzegovina (BA)
Publication Details
- Journal
- ADMET & DMPK
- Published
- 2025-09-04
- DOI
- https://doi.org/10.5599/admet.2861
- Primary Topic
- Inhalation and Respiratory Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00