Proinflammatory Cytokines Mediate Pancreatic β-Cell–Specific Alterations to Golgi Integrity via iNOS-Dependent Mitochondrial Inhibition
Proinflammatory cytokines drive disruptions in Golgi structure and function in human, mouse, and rat β-cells. Golgi alterations result from inducible nitric oxide synthase (iNOS)- and nitric oxide (NO)-dependent inhibition of mitochondrial metabolism. α-Cell Golgi structure is insensitive to cytokine- and NO-mediated metabolic inhibition. Analysis of human donor tissue shows early Golgi alteration in β-cells from autoantibody-positive donors, which persists in residual β-cells from T1D donors.
Authors
- Ling Yang (ORCID: https://orcid.org/0000-0002-3105-3063)
- Riley M. Behan-Bush (ORCID: https://orcid.org/0000-0003-2242-8545)
- Samuel B. Stephens (ORCID: https://orcid.org/0000-0003-1152-2691)
- Sandra E. Blom (ORCID: https://orcid.org/0000-0002-7112-5404)
- James A. Ankrum (ORCID: https://orcid.org/0000-0003-3959-6158)
- Palin R. Narsian
Institutions
- University of Iowa (US)
- Fraternal Order of Eagles (US)
Publication Details
- Journal
- Diabetes
- Published
- 2025-09-04
- DOI
- https://doi.org/10.2337/db25-0132
- Citations
- 2
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- U.S. Department of Defense
- National Institutes of Health