DDR2 Confers Ferroptosis Resistance to Cancer-Associated Fibroblasts and Attenuates PARPi Sensitivity of Ovarian Tumor Cells
The action of the collagen receptor tyrosine kinase DDR2 in CAFs confers PARPi protection to ovarian tumor cells by protecting CAFs from ferroptosis.
Authors
- Katherine C. Fuh (ORCID: https://orcid.org/0000-0002-7693-2694)
- Mary M. Mullen (ORCID: https://orcid.org/0000-0002-2976-5141)
- Julien Lesage (ORCID: https://orcid.org/0009-0006-2515-9095)
- Alessandra DiMauro (ORCID: https://orcid.org/0000-0002-2439-9517)
- Angela M. Schab (ORCID: https://orcid.org/0000-0003-1569-2452)
- Gregory D. Longmore (ORCID: https://orcid.org/0000-0001-7568-8151)
- Seth Stidham (ORCID: https://orcid.org/0009-0007-5732-0231)
Institutions
- University of California, San Francisco (US)
- Washington University in St. Louis (US)
- University of California System (US)
Publication Details
- Journal
- Molecular Cancer Research
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1158/1541-7786.mcr-25-0268
- Citations
- 3
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 4.56