Photoinduced Palladium-Catalyzed C(sp<sup>3</sup>)–H Phosphinoylation of Tetrahydroisoquinoline with Cl-Phosphine Oxide
A photoinduced palladium-catalyzed radical C(sp<sup>3</sup>)-H phosphinoylation of tetrahydroisoquinoline was reported. Easily accessible and inexpensive Cl-phosphine oxides were employed as phosphorus radical sources. The key steps in this strategy involve the generation of phosphorus and carbon radicals using the excited palladium complex.
Authors
- Li‐Wen Xu (ORCID: https://orcid.org/0000-0001-5705-0015)
- Zheng Xu (ORCID: https://orcid.org/0000-0003-4704-0846)
- Jian Cao (ORCID: https://orcid.org/0000-0002-7782-0299)
- Fei Ye (ORCID: https://orcid.org/0000-0002-4368-0267)
- Xuesong Wang (ORCID: https://orcid.org/0000-0002-8445-4952)
Institutions
- Hangzhou Normal University (CN)
- Westlake University (CN)
- Chemical Synthesis Lab (SG)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1021/acs.joc.5c01483
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Hangzhou Normal University
- Natural Science Foundation of Zhejiang Province