Investigation of Anticancer Properties of Newly Synthesized Pyridazine-Based Inhibitors in Mouse and Human Breast Cancer Cell Line
2S-13 appears to be a promising drug candidate, particularly in the MDA-MB-231 cell line. However, the current findings are limited to in vitro models. Further in vivo studies and pharmacokinetic analyses are required to validate its therapeutic potential, assess long-term efficacy and safety, and explore its resistance profile and molecular mechanisms in more detail.
Authors
- Kübra Açıkalın Coşkun (ORCID: https://orcid.org/0000-0002-0047-8368)
- Yusuf Tutar (ORCID: https://orcid.org/0000-0003-2613-9644)
- İrfan Koca (ORCID: https://orcid.org/0000-0001-7873-159X)
- Levent Gülüm
- Mehmet Gümüş (ORCID: https://orcid.org/0000-0003-1240-8284)
- Elif Cansu Abay (ORCID: https://orcid.org/0009-0000-3746-2004)
- Ayşe Büşranur Çelik (ORCID: https://orcid.org/0009-0005-7771-2414)
Institutions
- Recep Tayyip Erdoğan University (TR)
- Yozgat Bozok Üniversitesi (TR)
- Sağlık Bilimleri Üniversitesi (TR)
- Institute of Occupational Safety (SI)
- Istanbul University (TR)
- Bolu Abant İzzet Baysal University (TR)
- University of Health Sciences Antigua (AG)
Publication Details
- Journal
- Biology
- Published
- 2025-09-04
- DOI
- https://doi.org/10.3390/biology14091193
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Türkiye Bilimsel ve Teknolojik Araştırma Kurumu