Deficiency of p27 <sup>kip1</sup> , a Cyclin-Dependent Kinase Inhibitor, Accelerates Topical Elastase/3-Aminopropionitrile Fumarate Salt-Induced Abdominal Aortic Aneurysm Development in Mice
Knockout of p27 accelerated aneurysm growth with increased macrophage infiltration, VSMC loss, and decreased antioxidant factors, highlighting a potential role for p27 in AAA progression. .
Authors
- Keisuke Kamada (ORCID: https://orcid.org/0000-0001-7034-4376)
- Hong Niu
- Nobuyoshi Azuma (ORCID: https://orcid.org/0000-0003-2247-9860)
- Shinsuke Kikuchi (ORCID: https://orcid.org/0000-0002-5314-1603)
- Gale L. Tang (ORCID: https://orcid.org/0000-0001-5301-8229)
Institutions
- Asahikawa Medical University (JP)
- University of Washington (US)
- VA Puget Sound Health Care System (US)
Publication Details
- Journal
- Journal of Vascular Research
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1159/000547829
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00