Assessment of Miss Match repair proteins (MLH1 and MSH2) and p53 immunohistochemical expression in prostatic carcinoma: association with different clinicopathologic characteristics
MMR protein loss, especially MSH2, was seen in a significant subset of PCa. Interestingly, it was associated with significantly higher levels of serum PSA and p53. Moreover, it may be associated with unfortunate prognostic features as large tumour size, higher grade grouping and finally nodal and distant metastasis.
Authors
- Eman E. Farghal (ORCID: https://orcid.org/0000-0002-7562-055X)
- Basma Amer
- Hend Salah Ali Abo Safia
- Ahmed Ghaith (ORCID: https://orcid.org/0000-0002-9102-1821)
Institutions
- University of Jordan (JO)
- Tanta University (EG)
- Orchid Pharma (India) (IN)
- ORCID (US)
Publication Details
- Journal
- ecancermedicalscience
- Published
- 2025-09-04
- DOI
- https://doi.org/10.3332/ecancer.2025.1985
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00