Benefit–risk of colchicine and spironolactone in acute myocardial infarction: a prespecified generalised pairwise comparisons analysis of the CLEAR trial
In patients with post-MI, both low-dose colchicine and spironolactone demonstrated disadvantageous benefit-risk profiles, reinforcing that neither agent should be used routinely. This prespecified application of GPC provided results consistent with traditional methods but offered a clinically intuitive framework for interpreting composite outcomes.
Authors
- Matthias Bossard (ORCID: https://orcid.org/0000-0002-1587-2819)
- Marc-André d’Entremont (ORCID: https://orcid.org/0000-0002-1432-7384)
- David J. Austin (ORCID: https://orcid.org/0000-0003-4606-1055)
- Sanjit S. Jolly (ORCID: https://orcid.org/0000-0003-2329-2504)
- Rajibul Mian (ORCID: https://orcid.org/0000-0002-6377-405X)
- Jan Hein Cornel (ORCID: https://orcid.org/0000-0002-1006-2112)
- Emilie P. Belley‐Côté (ORCID: https://orcid.org/0000-0002-5071-076X)
- Valon Asani
- Faisal Alharthi
- Warren J. Cantor (ORCID: https://orcid.org/0000-0002-7715-6746)
- Jessica Tyrwhitt
- Shun Fu Lee (ORCID: https://orcid.org/0000-0001-9795-1045)
- Andrew Czarnecki (ORCID: https://orcid.org/0000-0002-3000-9722)
- Farzin Beygui (ORCID: https://orcid.org/0000-0003-2170-8983)
- Joshua Betz (ORCID: https://orcid.org/0000-0003-4488-9799)
- Robert F. Storey (ORCID: https://orcid.org/0000-0002-6677-6229)
- Johanne Silvain (ORCID: https://orcid.org/0000-0002-1901-2808)
- Jeroen Jaspers Focks
- Goran Stanković (ORCID: https://orcid.org/0000-0002-9414-0885)
- Binita Shah (ORCID: https://orcid.org/0000-0001-8872-8001)
- Nicholas Valettas (ORCID: https://orcid.org/0000-0002-7572-4340)
- James Spratt (ORCID: https://orcid.org/0000-0001-8719-4538)
- Michael Tsang (ORCID: https://orcid.org/0000-0003-1106-7609)
- Quilong Yi
- Payam Dehghani
- Sasko Kedev
- Shahar Lavi (ORCID: https://orcid.org/0000-0002-6105-8084)
- John W. Eikelboom (ORCID: https://orcid.org/0000-0003-4126-1285)
Institutions
- State University of Tetova (MK)
- Sunnybrook Health Science Centre (CA)
- Radboud University Nijmegen (NL)
- University of Ottawa (CA)
- London Health Sciences Centre (CA)
- St George’s University Hospitals NHS Foundation Trust (GB)
- Centre Hospitalier Universitaire de Sherbrooke (CA)
- Southlake Regional Health Center (CA)
- Health Sciences Centre (CA)
- Population Health Research Institute (CA)
- Radboud University Medical Center (NL)
- Sorbonne Université (FR)
- South West London and St George's Mental Health NHS Trust (GB)
- Assistance Publique – Hôpitaux de Paris (FR)
- Genome Prairie (CA)
- Sheffield Teaching Hospitals NHS Foundation Trust (GB)
- Centre Hospitalier Universitaire de Caen Normandie (FR)
- Luzerner Kantonsspital (CH)
- Société Française de Cardiologie (FR)
- PHI University Psychiatric Clinic - Skopje (MK)
- New York University (US)
- Hamilton Health Sciences (CA)
- Newcastle University (GB)
- University of Sheffield (GB)
Publication Details
- Journal
- Heart
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1136/heartjnl-2025-326218
- Citations
- 2
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 2.59
Funders
- Boston Scientific Corporation
- Canadian Institutes of Health Research
- Institute of Circulatory and Respiratory Health