Performance Analysis of Fiber-Optic Sensor for Skin Cancer Detection

Cancer continues to pose significant risk to human health. Among the different types of cancers, skin cancer is emerging as a growing concern worldwide. Early and accurate diagnosis improves treatment outcomes and patient survival rates. This study proposes a biosensor based on surface plasmon resonance (SPR) to facilitate the early identification of skin cancer. The sensor incorporates a multilayered structure consisting of gold (Au), titanium dioxide (TiO<inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf>), aluminium (Al), and MXene (Ti<inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf>C<inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf>T<inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</inf>), which relies on the variation in refractive indices between cancerous and normal cells. For cancer cells, the sensing probe exhibits a maximum sensitivity of 6250 nm/RIU. The proposed biosensing probe has the potential to facilitate the development of noninvasive diagnostic tools for early-stage skin cancer detection, contributing to improved healthcare outcomes.