Experimental In Vivo Evidence of the Prognostic Significance of Beta-III Tubulin (TUBB3) as a Molecular Marker of Tumor Metastatic Aggressiveness
Comparative immunofluorescence analysis of TUBB3 expression in primary and metastatic tissues from transplanted mouse tumors demonstrates a marked increase in both the level and intensity of TUBB3 expression in highly metastatic Lewis lung carcinoma, relative to the less metastatic LC-67 tumor. These in vivo findings give experimental evidence that the tumor-associated protein TUBB3 contributes to metastatic potential and underscore its relevance as a prognostic marker of tumor aggressiveness.
Authors
- Т. А. Богуш (ORCID: https://orcid.org/0000-0002-7673-4284)
- А. Н. Гришанина
- Mikhail Ya. Melnikov (ORCID: https://orcid.org/0000-0002-9712-8929)
- Alexander M. Scherbakov (ORCID: https://orcid.org/0000-0002-2974-9555)
- В. С. Косоруков (ORCID: https://orcid.org/0000-0002-8462-2178)
- Е. А. Богуш (ORCID: https://orcid.org/0000-0001-5601-3669)
- S. A. Kaliuzhny (ORCID: https://orcid.org/0000-0002-8701-7707)
Institutions
- Sechenov University (RU)
- Lomonosov Moscow State University (RU)
- Gause Institute of New Antibiotics Russian Academy of Medical Sciences (RU)
- Ministry of Health of the Russian Federation (RU)
Publication Details
- Journal
- Moscow University Chemistry Bulletin
- Published
- 2025-09-04
- DOI
- https://doi.org/10.3103/s0027131425700336
- Primary Topic
- Cancer therapeutics and mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00