A randomised placebo-controlled study of the effects of lysergic acid diethylamide microdosing (15 μg) on pain perception in healthy volunteers
Overall, the present study provided no evidence for analgesic effects of 15 µg LSD. Post-hoc analyses only revealed a marginal analgesic effect of LSD in a subsample of participants. The dose used in this study may be below the threshold dose that is needed to produce a solid and consistent analgesic effect. Future research with larger, appropriately selected samples and higher doses is recommended to further elucidate LSD's analgesic effects and its application in clinical settings.
Authors
- Jan Schepers (ORCID: https://orcid.org/0000-0002-6511-7651)
- Kim P. C. Kuypers (ORCID: https://orcid.org/0000-0001-7634-3809)
- Johannes G. Ramaekers (ORCID: https://orcid.org/0000-0003-4553-376X)
- Eef L. Theunissen (ORCID: https://orcid.org/0000-0002-6071-1758)
- Mauro Cavarra (ORCID: https://orcid.org/0000-0002-5216-3157)
- Natasha L. Mason (ORCID: https://orcid.org/0000-0001-7115-0389)
- Nadia R. P. W. Hutten (ORCID: https://orcid.org/0000-0003-0033-8119)
- Amanda Feilding (ORCID: https://orcid.org/0000-0002-1329-1893)
- Matthias E. Liechti (ORCID: https://orcid.org/0000-0002-1765-9659)
- Valérie Bonnelle (ORCID: https://orcid.org/0000-0002-4673-0549)
Institutions
- Beckley Foundation (GB)
- University of Basel (CH)
- University Hospital of Basel (CH)
- Maastricht University (NL)
Publication Details
- Journal
- British Journal of Pain
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1177/20494637251371626
- Primary Topic
- Psychedelics and Drug Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00