REAC Neurobiological Modulation With Neuro Postural Optimization (NPO) and Neuro Muscular Optimization (NMO) in Early Post-stroke Recovery: Functional Outcomes, Mechanistic Rationale, and Implications for Neurorehabilitation

Stroke remains a leading cause of long-term disability worldwide, and early intervention is critical for optimizing neurorehabilitative outcomes by capitalizing on the heightened neuroplasticity of the acute and subacute phases. This study aimed to evaluate whether the integration of Radio Electric Asymmetric Conveyer (REAC) neurobiological modulation protocols, Neuro Postural Optimization (NPO) and Neuro Muscular Optimization (NMO), into early post-stroke rehabilitation can accelerate and enhance functional recovery compared to conventional rehabilitation alone. Thirteen patients (nine males, four females; age range: 56-86 years; mean: 74) received a single NPO session, followed by an intensive cycle of 10 NMO sessions distributed over five to six consecutive days. Treatment efficacy was evaluated using the Barthel Index (BI), the items from the mobility section of the Fugl-Meyer Assessment (FMA) motor function scale, and the assessment of functional dysmetria (FD). The REAC-treated cohort demonstrated marked improvements, with BI increasing from a mean of 33 to 68 and the items from the mobility section of the FMA from 9.0 to 17.3. FD, present in all patients at baseline, resolved completely after the NPO session and remained absent. A historical control group (n=13; 8 males, 5 females; age range: 56-94 years; mean: 76), matched for age and clinical condition, underwent standard rehabilitation without REAC interventions. This group showed more modest gains (BI from 36 to 67; items from the mobility section of the FMA from 8.9 to 15.3) despite a longer average hospitalization duration (34.4 days vs. 30.8 days in the REAC group). No adverse effects or complications were reported in the REAC-treated patients. These findings highlight the potential of REAC NPO and NMO protocols to support and enhance functional recovery when applied in the critical early stages of stroke rehabilitation. Further prospective controlled trials are warranted to validate these results and explore the mechanistic underpinnings of REAC-mediated neuromodulation in post-stroke recovery.