Deficiency of Ugcg in LSECs alleviates high-fat diet-induced MASLD
Our findings establish UGCG as a master regulator of LSEC metabolic functions through GM3-IRβ axis modulation. LSEC-targeted UGCG inhibition mitigates hepatic insulin resistance via NO/ET-1-mediated hepatocyte metabolic reprogramming, providing a novel therapeutic paradigm for MASLD.
Authors
- Liangliang Ren (ORCID: https://orcid.org/0000-0001-6219-4304)
- Ying Jiang
- Weiran Lin
- Yanyan Li (ORCID: https://orcid.org/0009-0005-7231-9293)
- Yuhui Liu (ORCID: https://orcid.org/0000-0002-3095-5858)
- Rui Han
- Manman Li
Institutions
- Qualcomm (United Kingdom) (GB)
- Beijing Proteome Research Center (CN)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1097/hc9.0000000000000793
- Citations
- 1
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.81