Timing Genomic Antigen Loss in Multiple Myeloma Treated with T Cell–Redirecting Immunotherapies
Multiple myeloma has been demonstrated to recurrently develop resistance to T-cell redirection via genomic antigen escape. By leveraging chemotherapy mutational signatures, we demonstrate that somatic antigen-escape mechanisms are uniformly acquired following treatment initiation and not selected from among preexisting clones, emphasizing the importance of dynamic longitudinal surveillance for their emergence. See related commentary by Kauer et al., p. 532.
Authors
- Benjamin T. Diamond (ORCID: https://orcid.org/0000-0002-8638-9365)
- Marietta Truger (ORCID: https://orcid.org/0000-0002-2286-0656)
- Leo Rasche (ORCID: https://orcid.org/0000-0002-9536-9649)
- John B. McIntyre (ORCID: https://orcid.org/0000-0003-3135-8227)
- Sungwoo Ahn (ORCID: https://orcid.org/0000-0002-7688-6843)
- Holly Lee (ORCID: https://orcid.org/0000-0001-8353-0848)
- Katalin Osz (ORCID: https://orcid.org/0009-0007-1053-5454)
- Bachisio Ziccheddu (ORCID: https://orcid.org/0000-0002-2746-0053)
- Marios Papadimitriou (ORCID: https://orcid.org/0009-0009-1852-3495)
- Paola Neri (ORCID: https://orcid.org/0000-0002-2595-3647)
- Nizar Jacques Bahlis (ORCID: https://orcid.org/0000-0001-7353-7034)
- Michael Durante (ORCID: https://orcid.org/0000-0003-3137-6847)
- Ola Landgren (ORCID: https://orcid.org/0000-0001-6485-4839)
- Francesco Maura (ORCID: https://orcid.org/0000-0002-5017-1620)
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- University of Miami (US)
- University of Calgary (CA)
- Munich Leukemia Laboratory (Germany) (DE)
- Occupational Cancer Research Centre (CA)
- Universitätsklinikum Würzburg (DE)
- Sylvester Comprehensive Cancer Center (US)
Publication Details
- Journal
- Blood Cancer Discovery
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1158/2643-3230.bcd-25-0005
- Citations
- 2
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.54