Impact of Human Epidermal Growth Factor Receptor 2 in Patients With Metastatic Colorectal Cancer Treated With Chemotherapy Plus Bevacizumab or Anti-EGFRs: Exploratory Analysis of Eight Randomized Trials
To our knowledge, this is the largest analysis of HER2 status in patients with untreated mCRC enrolled in RCT. Waiting for targeted approaches, HER2-pos and mut do not predict benefit from bev/anti-EGFRs and should be regarded as negative prognostic factors in pMMR/MSS <i>RAS/BRAF</i> wild-type mCRC.
Authors
- Junpei Soeda (ORCID: https://orcid.org/0000-0003-3753-0999)
- Marco Maria Germani (ORCID: https://orcid.org/0000-0002-1036-5869)
- Clara Ugolini (ORCID: https://orcid.org/0000-0002-3489-8280)
- Arndt Stahler (ORCID: https://orcid.org/0000-0003-1041-0137)
- Kohei Shitara (ORCID: https://orcid.org/0000-0001-5196-3630)
- Yoshiaki Nakamura (ORCID: https://orcid.org/0000-0002-5241-6855)
- Francesca Battaglin (ORCID: https://orcid.org/0000-0002-9869-0163)
- Lisa Salvatore (ORCID: https://orcid.org/0000-0003-3864-0719)
- Francesca Bergamo (ORCID: https://orcid.org/0000-0002-8795-4653)
- Tadayoshi Hashimoto (ORCID: https://orcid.org/0000-0003-3759-1214)
- Alan P. Venook (ORCID: https://orcid.org/0000-0001-9749-6548)
- Heinz‐Josef Lenz (ORCID: https://orcid.org/0000-0003-2178-9568)
- Sara Lonardi (ORCID: https://orcid.org/0000-0002-7593-8138)
- Dominik Paul Modest (ORCID: https://orcid.org/0000-0002-6853-0599)
- Takayuki Yoshino (ORCID: https://orcid.org/0000-0002-0489-4756)
- Eiji Oki (ORCID: https://orcid.org/0000-0002-9763-9366)
- Beatrice Borelli (ORCID: https://orcid.org/0000-0002-9739-408X)
- Kei Muro (ORCID: https://orcid.org/0000-0002-5572-743X)
- Filippo Pietrantonio (ORCID: https://orcid.org/0000-0002-8530-8420)
- Carlotta Antoniotti (ORCID: https://orcid.org/0000-0001-6881-3188)
- Simone Oldani (ORCID: https://orcid.org/0009-0004-8589-3502)
- Chiara Cremolini (ORCID: https://orcid.org/0000-0002-0520-4841)
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Pisa (IT)
- Kyushu University (JP)
- Agostino Gemelli University Polyclinic (IT)
- Istituto Oncologico Veneto (IT)
- USC Norris Comprehensive Cancer Center (US)
- Aichi Cancer Center (JP)
- National Cancer Center Hospital East (JP)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Azienda Ospedaliera Universitaria Pisana (IT)
- UCSF Helen Diller Family Comprehensive Cancer Center (US)
- Takeda (Japan) (JP)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1200/jco-25-01003
- Citations
- 10
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 10.45