Cerebrovascular Reactivity at Rest and Its Association With Cognitive Function in People With Genetic Frontotemporal Dementia

CVR impairment in genetic FTD has a predilection for the middle frontal and posterior cortex, and its preservation may yield a cognitive benefit for at-risk individuals. Although findings do not provide causality and warrant replication, they support the notion that vascular dysfunction in familial FTD may be a target for biomarker identification and disease-modifying efforts.

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Journal
Neurology
Published
2025-09-04
DOI
https://doi.org/10.1212/wnl.0000000000213677
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00

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article

Cerebrovascular Reactivity at Rest and Its Association With Cognitive Function in People With Genetic Frontotemporal Dementia

Mattias Nilsson, Elisabeth Wlasich, Morris Freedman, David F. Tang‐Wai et al.
Neurology
Dementia and Cognitive Impairment Research
article

Cerebrovascular Reactivity at Rest and Its Association With Cognitive Function in People With Genetic Frontotemporal Dementia

Mattias Nilsson, Elisabeth Wlasich, Morris Freedman, David F. Tang‐Wai, Ron Keren, Kiran Samra, Koen Poesen, John Cornelis Van Swieten, Maura Malpetti, Alexander Bernhardt, Sandro Sorbi, Robert Bartha, Stefano Chiti, Rick van Minkelen, Carolina Maruta, Caroline Graff, Ekaterina A. Rogaeva, Philip Van Damme, Alazne Gabilondo, Andrea Arighi, Liset de Boer, Valentina Bessi, Raffaella Migliaccio, Maria Carmela Tartaglia, Jaume Olives, Tobias Christoph Langheinrich, Enrico Premi, James Benedict Rowe, Albert Lladó, Giorgio Giaccone, Alexander Gerhard, Lucia Giannini, Christopher Robert Butler, Roberto Gasparotti, María Serpente, Matthis Synofzik, Emanuele Buratti, Abbe Ullgren, Vesna Jelić, Lisa Graf, Johannes Levin, Johanna Krüger, Gemma Lombardi, Alexandre de Mendonça, Jolina Lombardi, Eve Ferry‐Bolder, Mircea Balasa, Anna Stockbauer, David M. Cash, Isabelle Le Ber, João Durães, David Mengel, Ivana Kancheva, Camilla Ferrari, Thomas Cope, Sara Prioni, Raquel Sánchez‐Valle, Sonja Schönecker, Veronica Redaelli, Rosa Rademakers, Núria Bargalló, Harro Seelaar, Jackie M. Poos, Sergi Borrego‐Écija, Pietro Tiraboschi, Frederico Simões do Couto, Ninon Burgos, Grégory Kuchcinski, Phoebe H. Foster, Benjamin Bender, Tiago Costa-Coelho, Arabella Bouzigues, Isabel Santana, Lize Corrine Jiskoot, Daisy Rinaldi, Enrico Fainardi, Cristina Polito, Martina Bocchetta, Annick Vogels, Antonella Alberici, Vittoria Borracci, Lucy Louise Russell, Jonathan D. Rohrer, Markus Otto, Rik R. Vandenberghe, Jan De Houwer, Elizabeth C. Finger, Patricia Alves, Elena Rodriguez‐Vieitez, Valentina Cantoni, Mathieu Vandenbulcke, Ioana Croitoru, Adeline Rollin, Chiara Fenoglio, Melissa Taheri Rydell, Ana Verdelho, Henrik Viklund, Catharina Prix, Miguel Tábuas‐Pereira, Marisa Lima, Kamen A. Tsvetanov, Vincent Deramecourt, Daniela Galimberti, Maria João Leitão, Maria Rosário Almeida, Mario Masellis, Emanuela Rotondo, Fermín Moreno, Robert Laforce, David Lee Thomas, Olivia Wagemann, Louise van der Weerd, Rhian S. Convery, Tiziana Carandini, Giuseppe Di Fede, João M. Lemos, Barbara Borroni, Pedro Rosa‐Neto, Sarah Anderl‐Straub, Miguel Castelo-Branco, Myriam Barandiarán, Yolande A.L. Pijnenburg, Mikel Tainta, Sara Berman Mitchell, Rose Bruffaerts, Simon Ducharme, Giacomina Rossi, Gabriel Miltenberger, Sònia Afonso, Anna Antonell, Christen Shoesmith, Sophie Goldsmith, Paola Caroppo, Janne M. Papma, Sandra Black, Benedetta Nacmias, Maxime Montembault
article en

Abstract

CVR impairment in genetic FTD has a predilection for the middle frontal and posterior cortex, and its preservation may yield a cognitive benefit for at-risk individuals. Although findings do not provide causality and warrant replication, they support the notion that vascular dysfunction in familial FTD may be a target for biomarker identification and disease-modifying efforts.

NeurologyVol. 105(6)
Western University (CA), Montreal Neurological Institute and Hospital (CA), Centre National de la Recherche Scientifique (FR), Allen Institute for Brain Science (US), Sunnybrook Health Science Centre (CA), Karolinska University Hospital (SE), University of Lisbon (PT), Inserm (FR), MRC Cognition and Brain Sciences Unit (GB), Universität Ulm (DE), University of Ferrara (IT), University of Cambridge (GB), Leiden University Medical Center (NL), German Center for Neurodegenerative Diseases (DE), McGill University Health Centre (CA), Nuffield Orthopaedic Centre (GB), Erasmus MC (NL), Cambridge University Hospitals NHS Foundation Trust (GB), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT), Karolinska Institutet (SE), Sorbonne Université (FR), Assistance Publique – Hôpitaux de Paris (FR), Biogipuzkoa Health Research Institute (ES), Institute for Neurodegenerative Disorders (US), Munich Cluster for Systems Neurology (DE), Centro San Giovanni di Dio Fatebenefratelli (IT), Don Carlo Gnocchi Foundation (IT), Pitié-Salpêtrière Hospital (FR), UK Dementia Research Institute (GB), Klinikum Arnsberg (DE), NIHR Queen Square Dementia Biomedical Research Unit (GB), Hertie Institute for Clinical Brain Research (DE), Institut du Cerveau (FR), VIB-KU Leuven Center for Brain & Disease Research (BE), Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES), Fondazione IRCCS Istituto Neurologico Carlo Besta (IT), Imaging Center (US), Université Laval (CA), University of Florence (IT), University College London (GB), Imperial College London (GB), McGill University (CA), University of Coimbra (PT), University of Brescia (IT), Ludwig-Maximilians-Universität München (DE), KU Leuven (BE)
Eli Lilly and Company, McGill University, Wellcome Trust, Sunnybrook Research Institute, Università degli Studi di Milano, Weston Brain Institute, Brain Research UK, McGill University Health Centre, Alzheimer's Society, National Institute for Health and Care Research, Department of Health and Social Care, Guarantors of Brain, University of Cambridge, Imperial College London, University College London, University of Oxford, Deutsche Forschungsgemeinschaft, Institut National de la Santé et de la Recherche Médicale, Universiteit Leiden, ZonMw, Bundesministerium für Bildung und Forschung, Cambridge University Hospitals, Erasmus Medisch Centrum, Ministero della Salute, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, University of Toronto, KU Leuven, Karolinska Institutet, Vetenskapsrådet, Università degli Studi di Firenze, Centre National de la Recherche Scientifique, Leids Universitair Medisch Centrum, Deutsches Zentrum für Neurodegenerative Erkrankungen, Universidade de Coimbra, Universidade de Lisboa, Universitat de Barcelona, Università degli Studi di Brescia, Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta, Universität Ulm, Stichting Dioraphte, Alzheimer Nederland, Dementias Platform UK, Tau Consortium, Medical Research Council, Instituto de Salud Carlos III, NIHR Cambridge Biomedical Research Centre
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Dementia and Cognitive Impairment Research
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