Deep Learning Modeling to Differentiate Multiple Sclerosis From MOG Antibody–Associated Disease
This study provides Class III evidence that both a clinical/MRI algorithm and an MRI-based DL model accurately distinguish RRMS from MOGAD.
Authors
- Carolina de Medeiros Rimkus (ORCID: https://orcid.org/0000-0002-3866-1299)
- Massimo Filippi (ORCID: https://orcid.org/0000-0002-5485-0479)
- Silvia Messina
- Bruno Stankoff (ORCID: https://orcid.org/0000-0002-9631-4674)
- Carsten Lukas (ORCID: https://orcid.org/0000-0002-8562-9697)
- Sara Llufriú (ORCID: https://orcid.org/0000-0003-4273-9121)
- Carla Tortorella (ORCID: https://orcid.org/0000-0001-9037-7300)
- Jaume Sastre‐Garriga (ORCID: https://orcid.org/0000-0002-1589-2254)
- Anu Jacob (ORCID: https://orcid.org/0009-0001-4217-2199)
- Sergiu Groppa (ORCID: https://orcid.org/0000-0002-2551-5655)
- Alvino Bisecco (ORCID: https://orcid.org/0000-0002-7202-4445)
- Matthias Grothe (ORCID: https://orcid.org/0000-0002-7998-5310)
- Nicola De Stefano (ORCID: https://orcid.org/0000-0003-4930-7639)
- Claudio Gasperini (ORCID: https://orcid.org/0000-0002-3959-4067)
- Rosa Cortese (ORCID: https://orcid.org/0000-0002-9803-7914)
- María Sepúlveda (ORCID: https://orcid.org/0000-0002-3078-645X)
- Marco Battaglini (ORCID: https://orcid.org/0000-0002-9188-4408)
- Serena Ruggieri (ORCID: https://orcid.org/0000-0001-5287-3290)
- Yaou Liu (ORCID: https://orcid.org/0000-0002-2965-0766)
- Jannis Müller (ORCID: https://orcid.org/0000-0003-1394-8231)
- Ruth Schneider (ORCID: https://orcid.org/0000-0002-0997-2725)
- Ferrán Prados (ORCID: https://orcid.org/0000-0002-7872-0142)
- Friedemann Paul (ORCID: https://orcid.org/0000-0002-6378-0070)
- Valentina Camera (ORCID: https://orcid.org/0000-0002-4925-9000)
- Luisa Pastò
- Matilde Inglese (ORCID: https://orcid.org/0000-0002-9610-0297)
- Àlex Rovira (ORCID: https://orcid.org/0000-0002-2132-6750)
- Andrea Lazzarotto (ORCID: https://orcid.org/0000-0002-5109-8533)
- Frederik Barkhof (ORCID: https://orcid.org/0000-0003-3543-3706)
- Ludovico Luchetti
- Olga Ciccarelli (ORCID: https://orcid.org/0000-0001-7485-1367)
- Mor Gueye
- Benedetta Bodini (ORCID: https://orcid.org/0000-0001-8010-1220)
- Massimiliano Calabrese (ORCID: https://orcid.org/0000-0002-3362-7403)
- Caterina Lapucci (ORCID: https://orcid.org/0000-0002-3527-6520)
- Samira Luísa Apóstolos‐Pereira (ORCID: https://orcid.org/0000-0003-3493-1199)
- Francesco Sforazzini (ORCID: https://orcid.org/0000-0003-2011-9394)
- Alessia Bianchi (ORCID: https://orcid.org/0000-0001-5541-5818)
- Georgina Arrambide (ORCID: https://orcid.org/0000-0002-2657-5510)
- Piotr Sowa (ORCID: https://orcid.org/0000-0003-4443-3628)
- Anne‐Katrin Pröbstel (ORCID: https://orcid.org/0000-0002-7748-1872)
- Elisabeth Gulowsen Celius (ORCID: https://orcid.org/0000-0002-9127-6488)
- Maria Assunta Rocca (ORCID: https://orcid.org/0000-0003-2358-4320)
- Cristina Granziera (ORCID: https://orcid.org/0000-0002-4917-8761)
- Barbara Bellenberg (ORCID: https://orcid.org/0000-0001-7484-6787)
- Antonio Gallo (ORCID: https://orcid.org/0000-0002-2203-6237)
- Douglas Kazutoshi Sato (ORCID: https://orcid.org/0000-0002-7695-6020)
- Giordano Gentile (ORCID: https://orcid.org/0000-0002-8481-2801)
- Romain Marignier (ORCID: https://orcid.org/0000-0002-5967-2800)
- Jacqueline A. Palace (ORCID: https://orcid.org/0000-0003-4779-6133)
- A. Mauro
- Maria Pia Amato
- Yunyun Duan
- Françoise Durand-Dubief
Institutions
- University of Siena (IT)
- University of Verona (IT)
- Universitat Autònoma de Barcelona (ES)
- Oslo University Hospital (NO)
- Centre National de la Recherche Scientifique (FR)
- Cleveland Clinic (US)
- Institut de la Vision (FR)
- Universitat Oberta de Catalunya (ES)
- University of Liverpool (GB)
- Vita-Salute San Raffaele University (IT)
- Inserm (FR)
- Queen Mary University of London (GB)
- Universidade de São Paulo (BR)
- Capital Medical University (CN)
- University of Basel (CH)
- Johannes Gutenberg University Mainz (DE)
- University of Campania "Luigi Vanvitelli" (IT)
- Max Delbrück Center (DE)
- Universitätsmedizin Greifswald (DE)
- Hawkeye Community College (US)
- University Hospital of Basel (CH)
- John Radcliffe Hospital (GB)
- Walton Centre (GB)
- National Institute for Health and Care Research (GB)
- Sorbonne Université (FR)
- Beijing Tian Tan Hospital (CN)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Assistance Publique – Hôpitaux de Paris (FR)
- Observatoire Français de la Sclérose en Plaques (FR)
- Hôpital Pierre Wertheimer (FR)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Don Carlo Gnocchi Foundation (IT)
- Siena Biotech (Italy) (IT)
- Pitié-Salpêtrière Hospital (FR)
- Vall d'Hebron Hospital Universitari (ES)
- IRCCS Ospedale San Raffaele (IT)
- St. Josef-Hospital (DE)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Ospedale Policlinico San Martino (IT)
- Carlo Forlanini Hospital (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- University of Florence (IT)
- University College London (GB)
- Pontifícia Universidade Católica do Rio Grande do Sul (BR)
- University of Genoa (IT)
- Vrije Universiteit Amsterdam (NL)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Neurology
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1212/wnl.0000000000214075
- Citations
- 3
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- National Science Foundation
- National Multiple Sclerosis Society
- Amgen
- Bristol-Myers Squibb
- Eli Lilly and Company
- AstraZeneca
- Sanofi
- Biogen
- Teva Pharmaceutical Industries
- Alexion Pharmaceuticals
- Celgene
- Fondazione Italiana Sclerosi Multipla
- Prothena
- Celltrion
- Argenx
- Horizon Therapeutics
- Multiple Sclerosis Society of Canada
- National Institute for Health and Care Research
- Guarantors of Brain
- University College London
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Bundesministerium für Bildung und Forschung
- Ministero della Salute
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Eisai
- Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
- University College London Hospitals NHS Foundation Trust
- H. Lundbeck A/S
- National Institutes of Health
- Novartis Pharma
- Chugai Pharmaceutical
- Sanofi Genzyme
- Instituto de Salud Carlos III