Immunoprofiling at an Institutional Scale Reveals That High Numbers of Intratumoral CD8 <sup>+</sup> and PD-1 <sup>+</sup> Cells Predict Superior Patient Survival Across Major Cancer Types Independent of Major Risk Factors
Routinely quantifying intratumoral CD8<sup>+</sup> and PD-1<sup>+</sup> cells with a clinically validated digital pathology platform predicts patient survival across major cancer types, independent of clinical stage and despite diverse treatment regimens.
Authors
- Jennifer Curtis
- Tali Mazor (ORCID: https://orcid.org/0000-0002-0138-9615)
- Xinan Wang (ORCID: https://orcid.org/0000-0001-5236-1105)
- Marta Holovatska (ORCID: https://orcid.org/0000-0002-0291-4960)
- Federica Pecci (ORCID: https://orcid.org/0009-0000-9289-2007)
- Sandro Santagata (ORCID: https://orcid.org/0000-0002-7528-9668)
- Eddy Saad (ORCID: https://orcid.org/0000-0001-8700-9312)
- Bijaya Sharma (ORCID: https://orcid.org/0000-0003-3432-1876)
- Melissa E. Hughes (ORCID: https://orcid.org/0000-0001-6190-9101)
- Jason L. Weirather (ORCID: https://orcid.org/0000-0003-0556-0616)
- Margaret A. Shipp (ORCID: https://orcid.org/0000-0002-3949-6897)
- Kristen D. Felt (ORCID: https://orcid.org/0000-0001-7063-8374)
- Jennifer Altreuter (ORCID: https://orcid.org/0000-0001-6545-6496)
- Biagio Ricciuti (ORCID: https://orcid.org/0000-0002-0651-2678)
- Tess A. O’Meara (ORCID: https://orcid.org/0000-0002-4778-2842)
- Neal I. Lindeman (ORCID: https://orcid.org/0000-0002-7092-6859)
- Glenn J. Hanna (ORCID: https://orcid.org/0000-0002-9969-2523)
- William Lotter
- Xiao X. Wei (ORCID: https://orcid.org/0000-0001-7093-0383)
- Sabina Signoretti (ORCID: https://orcid.org/0000-0002-5000-9105)
- Nancy U. Lin (ORCID: https://orcid.org/0000-0003-2263-5413)
- Toni K. Choueiri (ORCID: https://orcid.org/0000-0002-9201-3217)
- Bruce E. Johnson (ORCID: https://orcid.org/0000-0002-5252-3677)
- Jonathan Andrew Nowak (ORCID: https://orcid.org/0000-0002-0943-7407)
- Scott J. Rodig (ORCID: https://orcid.org/0000-0003-1761-9769)
- David Allen Barbie (ORCID: https://orcid.org/0000-0002-5422-4275)
- Katharina Hoebel (ORCID: https://orcid.org/0000-0002-1881-7065)
- Joyce F. Liu (ORCID: https://orcid.org/0000-0003-3888-3972)
- Peter Karl Sorger (ORCID: https://orcid.org/0000-0002-3364-1838)
- James Lindsay (ORCID: https://orcid.org/0000-0002-6295-098X)
- Elio Adib (ORCID: https://orcid.org/0000-0003-0594-7976)
- Sara M. Tolaney (ORCID: https://orcid.org/0000-0002-5940-8671)
- Michael P. Manos (ORCID: https://orcid.org/0000-0003-0841-207X)
- Frank S. Hodi
- Alessandro Di Federico (ORCID: https://orcid.org/0000-0001-8877-4315)
- Ethan Cerami (ORCID: https://orcid.org/0009-0009-2340-4490)
- Anita Giobbie‐Hurder (ORCID: https://orcid.org/0000-0003-2496-7737)
- Ian Dryg (ORCID: https://orcid.org/0000-0001-6173-2000)
- Kathleen L. Pfaff (ORCID: https://orcid.org/0000-0003-3311-5384)
- Panagiotis A. Konstantinopoulos (ORCID: https://orcid.org/0000-0002-1032-1479)
- Malini Gandhi (ORCID: https://orcid.org/0000-0002-8006-4148)
- Joao V. Alessi (ORCID: https://orcid.org/0000-0002-8072-5946)
- Mark M. Awad (ORCID: https://orcid.org/0000-0003-0928-5244)
- Sabrina Chan (ORCID: https://orcid.org/0000-0002-4557-2972)
- Lynette M. Sholl (ORCID: https://orcid.org/0000-0002-9532-9735)
- Priti Kumari (ORCID: https://orcid.org/0000-0002-2615-0125)
- Fatme Ghandour (ORCID: https://orcid.org/0000-0002-4091-0063)
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Cancer Research And Biostatistics (US)
- Dana-Farber Cancer Institute (US)
- Center for Systems Biology (US)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1200/po-25-00240
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 3.14