Next-Generation Sequencing of Intraoperatively Acquired Cerebrospinal Fluid and Matched Tumor Tissue in Patients Undergoing Surgical Resection for Glioblastoma
The addition of intraoperatively acquired CSF liquid biopsy to tissue NGS in patients with GBM may improve detection of clinically relevant variants, potentially improving selection of patients for clinical trials.
Authors
- Nike Beaubier (ORCID: https://orcid.org/0000-0002-1324-144X)
- Stephen Bagley (ORCID: https://orcid.org/0000-0002-7117-0539)
- Nduka Amankulor (ORCID: https://orcid.org/0000-0001-6217-1954)
- Arati Desai (ORCID: https://orcid.org/0000-0002-4849-4703)
- Erica L. Carpenter (ORCID: https://orcid.org/0000-0002-0735-3605)
- Dominique Ballinger (ORCID: https://orcid.org/0009-0003-8628-5536)
- Maikel Mansour (ORCID: https://orcid.org/0000-0002-3211-4905)
- Zev A. Binder (ORCID: https://orcid.org/0000-0003-1158-231X)
- Christina Jackson (ORCID: https://orcid.org/0000-0003-4210-7976)
- Timothy Prior (ORCID: https://orcid.org/0000-0001-9637-6421)
- Steven Brem (ORCID: https://orcid.org/0000-0002-5803-8920)
- Shivani Shah
- H. Isaac Chen (ORCID: https://orcid.org/0000-0002-7431-6046)
- Jacob E. Till (ORCID: https://orcid.org/0000-0002-2824-1282)
- Donald M. O’Rourke (ORCID: https://orcid.org/0000-0002-8479-7314)
- Eric L. Zager
- Carlos A. Leche (ORCID: https://orcid.org/0000-0002-6161-2671)
- Camilla Macia
- Thara Patel
- Melinda Yin
- Emily McCoy
Institutions
- Tempus Labs (United States) (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1200/po-25-00456
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00