Heterozygous Germline Fanconi Anemia–Related Gene Mutations Increase Susceptibility to Germ Cell Tumors
These results elucidate the contribution of FA-related germline variants to GCT pathogenesis and advance our understanding of the genetic determinants influencing GCT relative risk. This research provides a basis for developing more effective screening strategies, personalized treatment approaches, and improved patient management strategies for GCTs.
Authors
- Chunhua Wang (ORCID: https://orcid.org/0000-0001-7584-6113)
- Jing Wang (ORCID: https://orcid.org/0000-0003-1580-1356)
- Xiangyu Yin (ORCID: https://orcid.org/0000-0003-0193-3833)
- Tiantian Han (ORCID: https://orcid.org/0000-0002-4635-7174)
- Ningning Luo (ORCID: https://orcid.org/0000-0002-1991-1168)
Institutions
- University of Liverpool (GB)
- Shandong University (CN)
- Simcere Pharmaceutical (China) (CN)
- Xi’an Jiaotong-Liverpool University (CN)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1200/po-25-00435
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00