Prognostic Value of Dynamic Lactate Dehydrogenase Trends in Immunotherapy for Advanced Esophageal Squamous Cell Carcinoma: Retrospective Cohort Study
In patients with advanced ESCC, a decrease in serum LDH levels ranging from 0% to 14.4% after treatment initiation was significantly associated with prolonged PFS. Notably, an early decrease in LDH levels observed after 3 cycles of immunotherapy further correlated with improved clinical outcomes. These results highlight the potential of LDH as a valuable biomarker for risk stratification and personalized treatment optimization in advanced ESCC.
Authors
- Renya Zeng (ORCID: https://orcid.org/0000-0003-0667-8165)
- Zhiqiang Kang
- Yi Ding (ORCID: https://orcid.org/0000-0002-2158-3108)
- Yuanliu Nie
- Jing Wang (ORCID: https://orcid.org/0000-0002-2735-7283)
- Jianan Li (ORCID: https://orcid.org/0000-0001-5528-7107)
- Wentao Zhang (ORCID: https://orcid.org/0000-0003-4087-7280)
- Lu Sun (ORCID: https://orcid.org/0000-0003-2393-241X)
- Zhe Yang (ORCID: https://orcid.org/0000-0003-4082-6088)
- Yi Zhao (ORCID: https://orcid.org/0000-0003-4593-8353)
- Alei Feng
- B. Zhang
Institutions
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- JMIR Cancer
- Published
- 2025-09-04
- DOI
- https://doi.org/10.2196/73576
- Primary Topic
- Esophageal Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00