Allostatic Load Mediates Associations Between Race and Ethnicity and Hypertensive Disorders of Pregnancy
First-trimester allostatic load mediated the association between self-identified race and ethnicity and HDP for non-Hispanic Black and non-Hispanic White participants. This mediation effect was not observed in other racial and ethnic comparisons. These results demonstrate a physiologic pathway through which racism may contribute to adverse pregnancy outcomes and suggest that interventions targeting allostatic load reduction could help address racial and ethnic disparities in HDP.
Authors
- Mitali Ray (ORCID: https://orcid.org/0000-0002-7175-8287)
- Lisa Danielle Levine (ORCID: https://orcid.org/0000-0002-6811-7980)
- Yvette P. Conley (ORCID: https://orcid.org/0000-0002-1784-6067)
- Rebecca B. McNeil (ORCID: https://orcid.org/0000-0003-1351-1670)
- Lacey W. Heinsberg (ORCID: https://orcid.org/0000-0002-7690-5485)
- Amir J. Lueth (ORCID: https://orcid.org/0000-0002-2373-9372)
- Janet M. Catov (ORCID: https://orcid.org/0000-0002-9551-851X)
- C. Noel Bairey Merz (ORCID: https://orcid.org/0000-0002-9933-5155)
- Daniel E. Weeks (ORCID: https://orcid.org/0000-0001-9410-7228)
- Lynn M. Yee (ORCID: https://orcid.org/0000-0002-6274-0544)
- William A. Grobman
- R.M. Silver
Institutions
- National Institute of Environmental Health Sciences (US)
- Island Institute (US)
Publication Details
- Journal
- Obstetrics and Gynecology
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1097/aog.0000000000006062
- Citations
- 2
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 6.99
Funders
- National Institute of Nursing Research