Enhancing in-situ molecular profiling of gastric cancer for spatial proteomics through optimized digestion
We gained access to molecular information on tumor progression and treatment response by employing a tailored tryptic digestion protocol for MALDI-MSI detection. By advancing molecular profiling in gastric cancer, these findings provide valuable insight into disease-related molecular changes and contribute to developing more precise and personalized diagnostic strategies.
Authors
- Kristina Schwamborn (ORCID: https://orcid.org/0000-0003-3717-0823)
- Claire Delbridge (ORCID: https://orcid.org/0000-0003-4339-6917)
- Juliana Pereira Lopes Gonçalves (ORCID: https://orcid.org/0000-0002-6634-9876)
- Margaret Tulessin (ORCID: https://orcid.org/0009-0009-3854-5288)
- Bianca Grosser (ORCID: https://orcid.org/0000-0003-4957-4876)
- Tanja Groll (ORCID: https://orcid.org/0000-0002-9049-9145)
- Gisela Keller (ORCID: https://orcid.org/0000-0003-2886-0371)
- Louis Jung
- Julius Shakhtour
Institutions
- University of Augsburg (DE)
- Technical University of Munich (DE)
Publication Details
- Journal
- Analytica Chimica Acta
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1016/j.aca.2025.344607
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft