Activation and proliferation profiles of M.tuberculosis specific dual functional CD4+T cells from smear negative pulmonary TB patients
In this study, we found the diagnostic and prognostic potential of activation markers, particularly CD-38, in smear-negative PTB patients from dual M. tuberculosis-specific IFN-γ + TNF-α+ cytokine producing CD4 + T cells in both the presumed ex vivo and antigen-specific stimulation assays.
Authors
- Ahmed Esmael (ORCID: https://orcid.org/0000-0002-0310-0280)
- Sebsib Neway (ORCID: https://orcid.org/0000-0002-2033-5874)
- Rawleigh Howe (ORCID: https://orcid.org/0000-0002-4001-5456)
- Adane Mihret (ORCID: https://orcid.org/0000-0003-3183-4772)
- Daniel Mussa
- Liya Wassie (ORCID: https://orcid.org/0000-0002-5494-5275)
- Jyothi Rengarajan (ORCID: https://orcid.org/0000-0003-1241-4705)
- J. Ernst (ORCID: https://orcid.org/0000-0001-9951-6207)
- Tamrat Abebe (ORCID: https://orcid.org/0000-0002-6100-9303)
Institutions
- Emory University (US)
- University of California, San Francisco (US)
- Armauer Hansen Research Institute (ET)
- Addis Ababa University (ET)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-09-03
- DOI
- https://doi.org/10.1371/journal.pone.0327243
- Citations
- 1
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases
- Fogarty International Center