Baseline Single‐Cell Differences in Polyfunctionality Between Systemic Autoinflammatory Diseases Patients and Healthy Controls
Dysregulated cytokine secretion and signaling underlie systemic autoinflammatory diseases (SAIDs). Here, we characterized immune dysregulation in SAID patients by profiling cytokine secretion at the single-cell level, establishing measurements for secretion dynamics and cellular polyfunctionality, compared with healthy controls, revealing natural variability within immune responses between donors.
Authors
- Farah Diab (ORCID: https://orcid.org/0000-0003-4116-5082)
- Loïc de Pontual (ORCID: https://orcid.org/0000-0002-3123-0453)
- Irina Giurgea (ORCID: https://orcid.org/0000-0002-5035-2958)
- Klaus Eyer (ORCID: https://orcid.org/0000-0001-9344-5110)
- Aline Linder
Institutions
- Inserm (FR)
- Aarhus University (DK)
- ETH Zurich (CH)
- Sorbonne Université (FR)
- Hôpital Armand-Trousseau (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Jean-Verdier (FR)
- Expression Génétique Microbienne (FR)
Publication Details
- Journal
- European Journal of Immunology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/eji.70047
- Citations
- 1
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.80