Evaluation of the Safety of A Novel Anti-HER2 Immunotoxin Containing Modified Fragment of <i>Pseudomonas</i> Exotoxin in BALB/C Mice.
These findings revealed that the LD50 of scFv-PE35KDEL is in the range of 1000-2000 µg.mg<sup>-1</sup> and it seems to be a safe and non-toxic agent, and could be a promising candidate for anti-HER2 cancer therapy. However, further <i>in vivo</i> evaluations are required.
Authors
- Valiollah Hajhashemi (ORCID: https://orcid.org/0000-0001-5783-2324)
- Vajihe Akbari (ORCID: https://orcid.org/0000-0003-0754-1486)
- Azar Naimi (ORCID: https://orcid.org/0000-0002-7717-9112)
- Melika Kolahdoozan
- Fatemeh Saadatkhah
Institutions
- Isfahan University of Medical Sciences (IR)
Publication Details
- Journal
- PubMed
- Published
- 2025-04-01
- DOI
- https://doi.org/10.30498/ijb.2025.481960.4000
- Primary Topic
- Toxin Mechanisms and Immunotoxins
- Type
- article
- Field-Weighted Citation Impact
- 0.00