Exercise ameliorates hepatic lipid accumulation via upregulating serum PRL and activating hepatic PRLR-mediated JAK2/STAT5 signaling pathway in NAFLD mice
Exercise may moderately elevate serum prolactin (PRL) levels, thereby reducing intrahepatic lipid accumulation and ameliorating non-alcoholic fatty liver disease (NAFLD). The underlying mechanism may involve upregulation of the hepatic classical PRLR-mediated JAK2/STAT5 signaling pathway.
Authors
- Kaidi Nie
- Jia Fan (ORCID: https://orcid.org/0009-0000-9520-6762)
- Jiao Liu (ORCID: https://orcid.org/0000-0003-0304-241X)
- Xiaobing Liu (ORCID: https://orcid.org/0009-0009-4125-7383)
- Bei Shao (ORCID: https://orcid.org/0000-0002-0304-3052)
Institutions
- Chengdu Sport University (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-14
- DOI
- https://doi.org/10.3389/fphar.2025.1647231
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chengdu University of Traditional Chinese Medicine
- Chengdu University
- Maryland Population Research Center, University of Maryland