Effect of incretin-based therapies on blood pressure: a systematic review and meta-analysis

Incretin-based therapy led to a modest but clinically meaningful BP reduction and lower all-cause mortality in adults with overweight or obesity, without excess in hypoglycemia or pancreatitis episodes. There was a significant association between weight loss and the reduction in SBP and DBP. Dual and triple agonists exhibited the most pronounced antihypertensive effect. These findings support the use of incretin-based therapies as part of an integrated and multidisciplinary approach to managing obesity and hypertension, with multiple agonists showing particular promise. Our findings also underscore the need for long-term RCTs to clarify weight-independent mechanisms and the durability effect of BP reduction.

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Publication Details

Journal
European Journal of Preventive Cardiology
Published
2025-09-03
DOI
https://doi.org/10.1093/eurjpc/zwaf560
Citations
2
Primary Topic
Diabetes Treatment and Management
Type
article
Field-Weighted Citation Impact
2.59
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article

Effect of incretin-based therapies on blood pressure: a systematic review and meta-analysis

Mario Enrico Canonico, Francesco Orso, Carmine Morisco, Christian Basile et al.
2 citations
European Journal of Preventive Cardiology
Diabetes Treatment and Management
2.59
article

Effect of incretin-based therapies on blood pressure: a systematic review and meta-analysis

Mario Enrico Canonico, Francesco Orso, Carmine Morisco, Christian Basile, Carmine De Luca, Giuseppe Giugliano, Aurora Merolla, Costantino Mancusi, Giovanni Esposito, Ilaria Fucile
article en
2 citations

Abstract

Incretin-based therapy led to a modest but clinically meaningful BP reduction and lower all-cause mortality in adults with overweight or obesity, without excess in hypoglycemia or pancreatitis episodes. There was a significant association between weight loss and the reduction in SBP and DBP. Dual and triple agonists exhibited the most pronounced antihypertensive effect. These findings support the use of incretin-based therapies as part of an integrated and multidisciplinary approach to managing obesity and hypertension, with multiple agonists showing particular promise. Our findings also underscore the need for long-term RCTs to clarify weight-independent mechanisms and the durability effect of BP reduction.

European Journal of Preventive Cardiology
Vita-Salute San Raffaele University (IT), The Medical Center of Aurora (US), Karolinska Institutet (SE), Associazione Nazionale Medici Cardiologi Ospedalieri (IT), Mylan (South Africa) (ZA), Federico II University Hospital (IT), Health Care Foundation (CA), University of Naples Federico II (IT), University of Colorado Denver (US)
Openalex Percentile: Top 9%
Diabetes Treatment and Management
2.59
DOISourceOpenAlex
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Effect of incretin-based therapies on blood pressure: a systematic review and meta-analysis — Mario Enrico Canonico, Francesco Orso, et al. · European Journal of Preventive Cardiology (2025) | TGRS Research Map | TGRS