Hyperglycemia-induced overexpression of CREB3 L3 promotes the epithelial-to-mesenchymal transition in bladder urothelial cells in diabetes mellitus
Hyperglycemia induces the upregulation of CREB3 L3 expression, thereby promoting the EMT and impairing tight junctions in bladder urothelial cells. Targeting CREB3 L3 in bladder urothelial cells is likely to be a key approach in preventing and treating DCP.
Authors
- Weijin Fu
- Yibi Lan
- Miaomiao Zhang (ORCID: https://orcid.org/0000-0002-6388-649X)
- Chunlei Ma (ORCID: https://orcid.org/0000-0002-2993-7492)
- Qingguo Wu (ORCID: https://orcid.org/0000-0001-7994-9830)
Institutions
- Guigang City People's Hospital (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- World Journal of Diabetes
- Published
- 2025-08-14
- DOI
- https://doi.org/10.4239/wjd.v16.i8.108101
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 0.00