Passive physical barrier modulates UVB-induced METosis-related MPO expression and activity, 25-hydroxyvitamin D3-1alpha-hydroxylase, and the shift of tissue-resident macrophages toward M1-associated iNOS
UVB exposure enhances tissue-resident macrophage function in a preclinical rat model, increasing respiratory burst, phagocytosis, and M1-like polarization. The simulated barrier modulates these effects, notably by reducing MPO expression and METosis-related activity, which suggests a potential attenuation of excessive inflammation. These findings provide valuable insights relevant to human immune modulation and support further translational research. Future studies should investigate the role of circadian rhythms and other cell types in UVB- and vitamin D-mediated immune modulation.
Authors
- Rabia Messali (ORCID: https://orcid.org/0000-0002-5150-6373)
- Chafia Touil–Boukoffa (ORCID: https://orcid.org/0000-0001-7728-2147)
- Mourad Aribi (ORCID: https://orcid.org/0000-0002-6522-7252)
- Slimane Brikhou
- Zineb Mekkaoui
- Chahrazed El Mezouar
- Franck J. D. Mennechet (ORCID: https://orcid.org/0000-0001-6036-930X)
- Abdelouahab Bellou (ORCID: https://orcid.org/0000-0003-3457-5585)
- Souad Zoudji
- Xin Li (ORCID: https://orcid.org/0000-0003-2525-9679)
- Farah Sara Meterfi
- Nour Elhouda Bendjeffel
- Fadila Boudjelal
- Nawal Brikci Nigassa
Institutions
- Global Development Network (IN)
- Inserm (FR)
- Wayne State University (US)
- University of Abou Bekr Belkaïd (DZ)
- Research Center in Industrial Technologies (DZ)
- Biotechnology Research Center (IR)
- Établissement Français du Sang (FR)
- Dynamic Systems (United States) (US)
- Southern Medical University Shenzhen Hospital (CN)
- Guangdong Academy of Medical Sciences (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-14
- DOI
- https://doi.org/10.3389/fimmu.2025.1583493
- Citations
- 1
- Primary Topic
- Vitamin D Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.47