Myocardial PKG1α dysregulation contributes to ventricular tachycardia pathogenesis in type 2 diabetes and metabolic syndrome
In DMII and MBS, reduced PKG1α signaling drives GSK3β hyperstimulation, calcium dyshomeostasis, and VT. Pharmacologic modulation of these pathways opposes VT pathogenesis.
Authors
- Peiwen Liu (ORCID: https://orcid.org/0000-0003-2398-8798)
- Robert M. Blanton (ORCID: https://orcid.org/0000-0002-6837-2076)
- Mossab Aljuaid (ORCID: https://orcid.org/0000-0003-3920-2876)
- Gregory Martin
- Justin Ho
- Christopher Madias (ORCID: https://orcid.org/0009-0004-4009-5646)
- Rachael Steinhauer (ORCID: https://orcid.org/0000-0001-7785-7035)
- Abdullah Alissa
- Jonas Galper (ORCID: https://orcid.org/0000-0001-5737-9734)
- Bo Wang
- Xuehong Cao
- Yali Zhang
- Tina Phan
- Mark Aronovitz
- Audrey Tripp
Institutions
- Tufts University (US)
- Tufts Medical Center (US)
Publication Details
- Journal
- Heart Rhythm
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1016/j.hrthm.2025.08.032
- Primary Topic
- Heart Failure Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00