Second cancers in 475 000 women with early invasive breast cancer diagnosed in England during 1993-2016: population based observational cohort study
The risk of a second primary cancer in women treated for early invasive breast cancer is slightly higher than for women in the general population. Contralateral breast cancer accounts for around 60% of the overall increase, with higher risks in younger women. The risk associated with adjuvant therapies is small.
Authors
- David Dodwell (ORCID: https://orcid.org/0000-0001-8787-4904)
- David J. Cutter (ORCID: https://orcid.org/0000-0001-7307-7488)
- John Broggio (ORCID: https://orcid.org/0000-0001-9429-2275)
- Sarah C. Darby (ORCID: https://orcid.org/0000-0003-4046-0573)
- Gurdeep Mannu (ORCID: https://orcid.org/0000-0003-0219-9474)
- Paul McGale (ORCID: https://orcid.org/0009-0003-4112-3031)
- Alexander Williams (ORCID: https://orcid.org/0000-0003-2487-6667)
Institutions
- University of Exeter (GB)
- University of Oxford (GB)
- Oxford University Hospitals NHS Trust (GB)
- NHS England
Publication Details
- Journal
- BMJ
- Published
- 2025-08-27
- DOI
- https://doi.org/10.1136/bmj-2024-083975
- Citations
- 4
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.75
Funders
- Cancer Research UK
- National Institute for Health and Care Research
- University of Exeter
- University of Oxford