Effect of prenatal high-dose vitamin D on childhood atopic dermatitis is modified by maternal cotinine metabolome: A secondary analysis of a randomized clinical trial
This exploratory study of prespecified randomized clinical trial outcomes demonstrates effect modifications of the maternal tobacco exposure metabolome on the primary preventive effect of prenatal high-dose vitamin D on offspring atopic disease risk, suggesting a potential personalized prevention strategy targeting mothers exposed to tobacco smoking.
Authors
- Klaus Bønnelykke (ORCID: https://orcid.org/0000-0003-2003-1018)
- Lone Skov (ORCID: https://orcid.org/0000-0002-4784-9680)
- Bo Chawes (ORCID: https://orcid.org/0000-0001-6846-6243)
- Ann‐Marie Malby Schoos (ORCID: https://orcid.org/0000-0002-5827-0885)
- Jakob Stokholm (ORCID: https://orcid.org/0000-0003-4989-9769)
- Beatriz Jorge Oliveira Gomes (ORCID: https://orcid.org/0009-0006-1646-3415)
- Anika Klein (ORCID: https://orcid.org/0000-0003-1433-0863)
- Nicklas Brustad (ORCID: https://orcid.org/0000-0001-6383-8845)
- Hannah Kaiser (ORCID: https://orcid.org/0000-0002-5151-2482)
- Nilo Vahman (ORCID: https://orcid.org/0009-0005-3604-2602)
- Liang Chen (ORCID: https://orcid.org/0000-0001-5845-2235)
- Tingting Wang (ORCID: https://orcid.org/0000-0002-9100-3447)
Institutions
- University of Copenhagen (DK)
- Gentofte Hospital (DK)
- Copenhagen Prospective Studies on Asthma in Childhood (DK)
Publication Details
- Journal
- Journal of the American Academy of Dermatology
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1016/j.jaad.2025.08.044
- Citations
- 2
- Primary Topic
- Vitamin D Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- European Commission
- Lundbeckfonden
- H. Lundbeck A/S